...In addition to reversing abnormal keratinization, there is evidence that the topical retinoids may have some anti-inflammatory properties. Both adapalene (Differin®) and tretinoin have been shown to do this in different experiments. Because Retin-A has been on the market for more than 25 years, patients will frequently come in and say, "I've already used tretinoin; it didn't work." For many physicians, their first inclination is to try something else. My favorite therapy is a topical retinoid used in conjunction with a combination of benzoyl peroxide and erythromycin. ...»
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