« ...Retinoids Help Normalize KeratinizationAlthough the mechanism by which topical and systemic retinoids help restore acne follicles to a healthy state is unknown, it has been well demonstrated that they normalize keratinization within the infundibular region of the follicle, so that shed follicular cells slough to the surface of the skin rather than clump together and obstruct the pores.After exposure to retinoids, follicular cells actually turn over more rapidly than they would in a pre-acne state.Retinoic acid has a high affinity for the gamma retinoid receptors, which are believed to be integral to the pathogenesis of acne.In addition to their ability to reverse abnormal keratinization within the follicle, the topical retinoids - especially adapalene (Differin®), a naphthoic acid derivative - may have anti-inflammatory properties and thus may address two factors involved in the development of acne....
...In women, oral contraceptives can also be used in acne treatment. The oral contraceptives help by suppressing the overactive sebaceous glands. Contraceptives can be used over a long period of time. However, women who smoke or have a history of blood clots, may want to consider a different treatment alternative....»
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best-acne-remedies.blogspot.com «...Compared with topical therapy, systemic therapy has a more rapid onset of clearing, which may enhance patient compliance. However, whenever systemic drugs are administered, the potential dangers- including side effects, drug allergy/intolerance, drug interactions, and fetal exposure in women who are or may become pregnant-must be carefully considered. ...»
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